![]() The diagnosis of diabetic retinopathy depends on fundus examination, but it’s not good for routine screening, and the patient’s compliance is poor. The pathogenesis of diabetic retinopathy is not clear, relevant studies have shown that it may be associated with local microvascular injury and microcirculation disorders, and improving blood circulation of the retina effectively before or early in the emergence of DR may prevent it from developing. Diabetic retinopathy (DR), a kind of microvascular lesions occurring in fundus, accounts for 40 percent of diabetics over 40 years of age, and is the main cause of impaired vision and even blindness in diabetics. Type 2 diabetes mellitus is a common metabolic disease with all kinds of microvascular diseases occurring. ![]() The study demonstrated that increased MPV level was significant associated with the development of DR, and it might reflect the severity of DR, which could be provided to monitor development and progression of DR clinically. ![]() ![]() Subgroup analysis indicated that MPV level in proliferative diabetic retinopathy (PDR) patients was higher than T2DM without DR patients, but this difference didn’t appear in non-proliferative diabetic retinopathy (NPDR). Meta-analysis showed that MPV values in DR were significantly higher than health controls and type 2 diabetes mellitus without diabetic retinopathy (T2DM without DR). Finally, a total of 14 literatures included, and Review manager 5.3 and STATA 14.0 statistical software were utilized for processing. Literature was retrieved by formally searching PubMed, Embase, Cochrane library and Scopus and by hand searching of reference lists of related articles. ![]() Recent years, many studies reported mean platelet volume (MPV) may be associated with development of DR, but there was no consistent conclusion reached. Diabetic retinopathy (DR) is one of the most common diseases causing blindness in the world, and most patients are already in advanced stage. ![]()
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